proteolytic activity – Communicable Diseases Research

The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia Formation

Article

Published on 2022-10-262022-11-15
Journal: mBio
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제,

[키워드] acute respiratory syndrome appear assays catalytic caused Cell cell-cell fusion cell-cell fusion assay cells cellular cellular component cellular membrane contribute coronavirus coronavirus coronavirus SARS-CoV-2 Coronaviruses COVID-19 COVID-19 pandemic dead defend Defense Efficiency ENhance entry of SARS-CoV-2 examined Formation genetic knockout global public health host cell membranes IFITM IFITMs in viral include Infection inhibiting inhibitory activity innate immune innate immune response Integral interact Interaction interfere intrinsic knockdown lentivirus maturation mechanism membrane membrane protein MHV mouse hepatitis virus nuclear overexpression pandemic Plaque assay precursor prelamin A Prevent protease Proteases PROTECT Protective protective role Protein proteolytic proteolytic activity reduce required restriction factor restriction factor. SARS-CoV-2 SARS-CoV-2 pseudovirus infection shown spike Therapeutic benefit transmembrane protein viral infection viral infections virus virus entry viruses wild-type ZMPSTE24
[DOI] 10.1128/mbio.02543-22 PMC 바로가기

Ultrafast one-minute electronic detection of SARS-CoV-2 infection by 3CLpro enzymatic activity in untreated saliva samples

Article

Published on 2022-10-262022-11-15
Journal: Nature Communications
[Category] COVID19(2023년), SARS, 치료기술, 치료제,

Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation

Research

Published on 2022-06-082022-10-05
Journal: Nature chemical biology
[Category] COVID19(2023년), SARS, 치료제,

Inhibition of SARS-CoV-2 replication by zinc gluconate in combination with hinokitiol

히노키티올과 함께 글루콘산아연에 의한 SARS-CoV-2 복제 억제

Article

Published on 2022-06-012022-09-11
Journal: Journal of inorganic biochemistry
[Category] COVID19(2023년), SARS, 치료제,

[키워드] 3CLpro acute respiratory syndrome coronavirus antiviral therapy approach binding catalytic site chymotrypsin Combination Concentration coronavirus 2 coronavirus disease Coronavirus disease 2019 Coronavirus infections COVID-19 elevated Enzyme inhibition exhibited experimental evidence global public health gluconate hinokitiol in vitro inhibit inhibited inhibition inhibitory Ionophore mammalian cells metal ion MPro pandemic Papain Papain-like protease PLPro potential benefit potential benefits protease Protease activity Proteases protein structure proteolytic proteolytic activity residues respiratory SARS-CoV-2 SARS-CoV-2 replication screened Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 2 significantly small molecule target Treatment Zinc zinc gluconate Zinc gluconate.
[DOI] 10.1016/j.jinorgbio.2022.111777 PMC 바로가기 [Article Type] Article

Development of a biosensor assessing SARS-CoV-2 main protease proteolytic activity in living cells for antiviral drugs screening

항바이러스제 스크리닝을 위한 생체 내 SARS-CoV-2 주요 단백질 분해효소 단백질 분해 활성을 평가하는 바이오센서 개발

Article

Published on 2022-06-012022-09-11
Journal: Virologica Sinica
[Category] COVID19(2023년), SARS, 치료제,

[키워드] animal models antiviral drug biosensor development in vitro living cell living cells M pro MONITOR proteolytic activity reported SARS-CoV-2 SARS-CoV-2 main protease
[DOI] 10.1016/j.virs.2022.04.002 PMC 바로가기 [Article Type] Article

The SARS-CoV-2 main protease doesn’t induce cell death in human cells in vitro

SARS-CoV-2 주요 프로테아제는 시험관 내에서 인간 세포에서 세포 사멸을 유도하지 않습니다

Article

Published on 2022-05-242022-09-11
Journal: PLoS ONE
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, 치료제,

[키워드] 3CL 3CLpro acute respiratory syndrome acute respiratory syndrome coronavirus addition analyzed antiviral therapies Apoptosis Cell cell death cell line cell lines contribute coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus replication COVID-19 Cytopathic effect cytotoxicity detect develop effective enzyme expression homologous human cell human cell lines in vitro inactivated induce molecular mechanism molecular mechanisms morphology multifunctional Pathogenesis protease Protein proteolytic activity required SARS-CoV SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 pathogenesis severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown Spread the SARS-CoV-2 therapeutic target unlikely variant viability viral infection
[DOI] 10.1371/journal.pone.0266015 PMC 바로가기 [Article Type] Article

Heparin interacts with the main protease of SARS-CoV-2 and inhibits its activity

헤파린은 SARS-CoV-2의 주요 프로테아제와 상호작용하여 그 활성을 억제합니다.

Article

Published on 2022-02-152022-09-11
Journal: Spectrochimica acta. Part A, Molecular and biomole
[Category] COVID19(2023년), SARS, 치료제,

Aloin isoforms (A and B) selectively inhibits proteolytic and deubiquitinating activity of papain like protease (PLpro) of SARS-CoV-2 in vitro

Article

Published on 2022-02-092022-10-04
Journal: Scientific Reports
[Category] Coronavirus, COVID19(2023년), MERS, SARS, 변종, 치료제,

Atypical response to bacterial coinfection and persistent neutrophilic bronchoalveolar inflammation distinguish critical COVID-19 from influenza

박테리아 동시 감염 및 지속적인 호중구 기관지 폐포 염증에 대한 비정형 반응은 인플루엔자와 중요한 COVID-19를 구별합니다

Research Article

Published on 2022-01-112022-09-12
Journal: JCI Insight
[Category] 진단, 치료기술,

[키워드] activating Antibiotic treatment Bacterial bacterial coinfections BAL BAL fluid blood sample bronchoalveolar Bronchoalveolar lavage CCL7 chemokine chemokines chemotactic factor circulating Cohort collected comparable Concentration coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical Critically ill critically ill COVID-19 patients CXCL1 CXCL11 CXCL12 CXCL8 cytokine Cytokines decrease effector cell elafin elevated fluids G-CSF highlighting IL-1 β IL-17A IL-1ra Immunological response immunology Inflammation Influenza Invasive mechanical ventilation leukocyte lung Lungs Lymphocytes mechanically ventilated patient mechanically ventilated patients metalloproteinase Monocytes neutrophil neutrophilic Neutrophils NK cell NK cells parameter pathophysiology patients with COVID-19 patients with influenza Protease inhibitor protease inhibitors proteolytic activity severe coronavirus disease Tissue Inhibitor TNF- α Treatment Viral pneumonia
[DOI] 10.1172/jci.insight.155055 PMC 바로가기 [Article Type] Research Article

Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation

Chemistry

Published on 2021-11-152022-10-31
Journal: Frontiers in Chemistry
[Category] COVID-19,